THE PIEZOPORATION® SYSTEM,

DRIVES A CONCENTRATED

HYALURONAN FORMULA TROUGH THE SKIN

WITHOUT NEEDLES AND PAIN,

TO REJUVENATE YOUR LOOK.

Testimonies

“With LaserLeap treatment, my skin became firmer and my wrinkles diminished.”

Paula Cabrita, from Portugal

Skin permeation through piezoporation

When a nanosecond laser pulse is absorbed by our patented piezophotonic materials, laser light is very efficiently converted into a high-impulse (ultrasound) pressure wave. These high-impulse pressure waves make the skin temporarily permeable, facilitating the intraepidermal and intradermal delivery of cosmetics or drugs.

 

High-impulse pressure waves vs. typical ultrasound waves

The rise time of our high-impulse pressure waves is determined by the laser pulse’s duration (= 10 ns). Typical ultrasound waves pulse at about 1 MHz. Shorter laser pulses correspond to larger pressure-wave bandwidths, which allow us to produce pressure waves that extend out to hundreds of MHz. As such, our wavelengths resemble the length of the stratum corneum, our skin’s protective barrier (~15 µm), which causes internal pressure variations leading to a momentary breakdown of the skin’s structure.

 

Piezoporation Mechanism

The unperturbed stratum corneum, shown as 14 layers of tightly packed corneocytes with hydrophilic domains (blue) separated by intercellular lipid lamellae (green), where the diameter of a corneocyte (40 µm) is not to scale. A compressive front and rarefaction tail of a high-impulse pressure wave traversing the stratum corneum and producing very fast pressure changes. This causes the stratum corneum to expand and lacunar spaces (pores) to appear, where the organization of the lipid matrix is changed, which facilitates the diffusion of cosmetics and drugs through the expanded spaces. The skin’s functional barrier recovers after a few minutes.

 

Effectiveness

When a high-impulse pressure wave reaches the skin, it makes it temporarily permeable, allowing high-weight molecules to spread. Piezoporation enables hyaluronic acid (molecular weight of 1 MDa) to be evenly distributed across the epidermis without causing any structural or physiological changes to the skin.

No Pain

Testing done on human volunteers showed that piezoporation did not cause any pain after applying photoacoustic waves.

No Marks

Application of the photoacoustic waves produced by LaserLeap technology is practically imperceptible and does not give rise to erythema, inflammation or reddening of the skin. The skin’s structure is not permanently changed, and testing with volunteers helped to confirm that the skin’s protective barrier recovers in about 25 minutes.      

 

2014 Tech All Stars - European Commission. LaserLeap was selected as one of the 12 most-promising startups in Europe.  

2012 SPIE Photonics Startup Challenge. LaserLeap was selected as the best light-based technology startup at the top photonics conference in the world.

2010 AVCRI Award - RedEmprendia. LaserLeap was selected by RedEmprendia’s Agency for the Valuation and Commercialization of Research Results as the best scientific project from Ibero-American universities. 

2008 BES - Innovation Prize. Portugal’s most competitive innovation prize. Winner in the Health category, as well as the Grand Prize for all categories.

Photoacoustic waves as a skin permeation enhancement method.

Gonçalo F.F. Sá, Carlos Serpa, Luís G. Arnaut, “Percutaneous Permeation Enhancers”, N. Dragicevic-Curic, H. I. Maibach (Eds.), Springer, 2013.

Stratum corneum permeabilization with photoacoustic waves generated by piezophotonic materials.

Gonçalo F.F. Sá, Carlos Serpa, Luís G. Arnaut, Journal of Controlled Release. Volume 167, Issue 3, 2013, Pages 290-300

Device for the efficient delivery of compounds to or through the skin or biological barriers, using ligh-absorbing thin films.
Gonçalo F. F. Sá, Carlos A. L. Serpa Soares, Luis. G. S. Arnaut Moreira
Universidade de Coimbra. PT Patent Application no. 105635, 19 de Abril de 2011

Intense, high-frequency pressure waves produced with low laser fluences.
C. Serpa, G. F. F. Sá, L. G. Arnaut
SPIE Photonics West 2012

Analytical solution for time-resolved photoacoustic calorimetry data and applications to two typical photoreactions.
F.A. Schaberle, R.M.D. Nunes, M. Barroso, C. Serpa, L.G. Arnaut
Photochem. Photobiol. Sci., 9 (2010) 812-822.

Photoacoustic Measurement of Electron Injection Efficiencies and Energies from Excited Sensitizer Dyes into Nanocrystalline TiO2 Films.
C. Serpa, J. Schabauer, A.P. Piedade, C.J.P. Monteiro, M.M. Pereira, P. Douglas, H. D. Burrows, L.G. Arnaut
J. Am. Chem. Soc. 130 (2008) 8876-8877

Recent advances in photoacoustic calorimetry - theoretical basis and improvements in experimental design.
L. G. Arnaut, R. A. Caldwell, J. E. Elbert and L. A. Melton
Rev. Sci. Instrum., 1992, 63, 5381–5389. doi:10.1063/1.1143407

contact us

LASERLEAP TECHNOLOGIES


Coimbra

LaserLeap Technologies

Instituto Pedro Nunes

Rua Pedro Nunes, S/N

3030-199 Coimbra

 

Phone: +351 239 095 450

email: info@laserleap.com

 

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contact us

LASERLEAP TECHNOLOGIES


Coimbra

LaserLeap Technologies

Instituto Pedro Nunes

Rua Pedro Nunes, S/N

3030-199 Coimbra

 

Phone: +351 239 095 450

email: info@laserleap.com

 

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contact us

LASERLEAP TECHNOLOGIES


Coimbra

LaserLeap Technologies

Instituto Pedro Nunes

Rua Pedro Nunes, S/N

3030-199 Coimbra

 

Phone: +351 239 095 450

email: info@laserleap.com

 

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